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Schizophrenia and Schizotypal Personality may have Genetic R

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Schizophrenia and Schizotypal Personality may have Genetic R

Postby MGMT on Fri Aug 22, 2008 4:09 pm

Another interesting study, which labels Schizotypal Personality Disorder a neuropsychiatric disorder;

Schizophrenia and Schizotypal Personality may have Genetic Roots

Scientists at the National Institutes of Health (NIH) report in the September 5, 1997 issue of Cell that they have identified a gene that disrupts normal social behavior among laboratory mice missing that gene.

In addition, these mutant mice have abnormalities in sensorimotor gating - a process believed to be important in animals for filtering the multitude of stimuli that constantly bombard their senses and allowing them to focus on one stimulus at a time.

Sensorimotor gating defects are also believed to contribute to symptoms of several human neuropsychiatric disorders, including schizophrenia, schizotypal personality disorder, obsessive-compulsive disorder, Huntington's disease and Tourette syndrome. All of these human disorders appear to have genetic components, but the specific gene disrupted in these mice, dishevelled-1, has not previously been associated with any of them.


Full article here.
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Re: Schizophrenia and Schizotypal Personality may have Genetic R

Postby Piggsylamb on Sun Apr 26, 2009 11:48 pm

We both have mutant genes Schizophrenia and Schizotypal are different could even be evolution?
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Re: Schizophrenia and Schizotypal Personality may have Genetic R

Postby Karla on Mon Apr 27, 2009 3:03 pm

I'm not quite sure, what you're saying, Piggsylamb.

Are you saying that Schizotypal Personality Disorder is different from Schizophrenia, and that they're an outcome of evolution?
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Re: Schizophrenia and Schizotypal Personality may have Genetic R

Postby schizotypes on Thu Oct 29, 2009 12:36 am

I always thought I was an "X-man" Where is DR. Xavier when you need him?

Schizotypal, schizothymia, schizophrenia are all related under the schizo spectrum there are different levels of it, just like there are different levels of autism, in which Asperger's comes under.

Schizothymia- Schizothymia is a temperament related to schizophrenia in a way analogous to cyclothymia's relationship with bipolar disorder. A schizothymic individual displays a flat affect and a high degree of introversion, withdrawing from social relations generally; nevertheless, some individuals with this characteristic may be able to achieve a relatively affable social relations and a measure of affectivity in some situations. As a kind of temperament, schizothymic personality traits are thought to be more or less innate rather than the result of socialization (or a lack thereof).

Schizotypal Personaliy Disorder - The DSM-IV-TR, a widely used manual for diagnosing mental disorders, defines schizotypal personality disorder as:

A pervasive pattern of social and interpersonal deficits marked by acute discomfort with, and reduced capacity for, close relationships as well as by cognitive or perceptual distortions and eccentricities of behavior, beginning by early adulthood and present in a variety of contexts, as indicated by five (or more) of the following:
Ideas of reference (excluding delusions of reference)
Odd beliefs or magical thinking that influences behavior and is inconsistent with subcultural norms (e.g., superstitiousness, bizarre fantasies or preoccupations)
Unusual perceptual experiences, including bodily illusions
Odd thinking and speech (e.g., vague, circumstantial, metaphorical, overelaborate, or stereotyped)
Suspiciousness or paranoid ideation
Inappropriate or constricted affect
Behavior or appearance that is odd, eccentric, or peculiar
Lack of close friends or confidants other than first-degree relatives
Social anxiety that tends to be associated with paranoid fears rather than negative judgments about self.

Schizophrenia -
Schizophrenia (pronounced /ˌskɪtsɵˈfrɛniə/ or /ˌskɪtsɵˈfriːniə/), from the Greek roots skhizein (σχίζειν, "to split") and phrēn, phren- (φρήν, φρεν-; "mind") is a psychiatric diagnosis that describes a mental disorder characterized by abnormalities in the perception or expression of reality. Distortions in perception may affect all five senses, including sight, hearing, taste, smell and touch, but most commonly manifest as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking with significant social or occupational dysfunction. Onset of symptoms typically occurs in young adulthood,[1] with approximately 0.4–0.6%[2][3] of the population affected. Diagnosis is based on the patient's self-reported experiences and observed behavior. No laboratory test for schizophrenia currently exists.[4]

Now when it comes to Asperger's they share many commonalities but are two distinctly different disorders.
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